ParseMedica

Fig. 3.: Genomic and epidemiologic investigation of Mycobacterium abscessus isolates in a

Pulmonology Cystic Fibrosis

WGS separates person-to-person M. abscessus transmission from environmental exposure in CF centers.

Genomic and epidemiologic investigation of Mycobacterium abscessus isolates in a cystic fibrosis center to determine potential routes of transmission.

Whole-genome sequencing of M. abscessus isolates in a CF center distinguished healthcare-associated person-to-person transmission from environmental acquisition, informing targeted infection control strategies.

Parse B · Mar 11, 2026 · 4 min read

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Cystic fibrosis-related diabetes is associated with reduced airway microbial diversity.

CF-related diabetes correlated with reduced airway microbial diversity and heightened inflammation, helping explain the accelerated lung function decline seen in these patients.

Fig. 1: Cystic fibrosis-related diabetes is associated with reduced airway microbial div

Parse B Mar 11, 2026 · 4 min read

Pulmonology

B2m knockout enables universal donor basal cells. No autologous production. Allogeneic airway regeneration in reach.

CRISPR/Cas9-mediated B2m knockout paves the way for allogeneic basal cell transplantation.

This approach enables the creation of universal donor basal cells for airway regeneration therapy, eliminating the need for time-consuming autologous cell production and avoiding complications…

Fig. 5: CRISPR/Cas9-mediated B2m knockout paves the way for allogeneic basal cell transp

Parse B Mar 11, 2026 · 4 min read

Pulmonology

Largest GWAS of lung function decline to date. 43 approved drugs flagged as candidates to slow the loss.

Multi-ancestry genome-wide association study and meta-analysis of lung function decline.

This largest GWAS of lung function decline to date reveals the genetic architecture underlying accelerated lung function loss and identifies corticosteroids and 43 approved drug…

Fig. 2: Multi-ancestry genome-wide association study and meta-analysis of lung function

Parse B Mar 11, 2026 · 3 min read

Pulmonology

NNK links tobacco smoke to IPF at the molecular level. Specific pathways identified. Novel targets emerge.

Integrated network toxicology and multi-omics analysis reveals the role of tobacco-specific carcinogen NNK in idiopathic pulmonary fibrosis pathogenesis.

Integrated network toxicology and multi-omics analysis identified specific molecular pathways linking tobacco smoke to IPF pathogenesis, revealing novel therapeutic targets for this fatal progressive lung…

Fig. 3: Integrated network toxicology and multi-omics analysis reveals the role of tobac

Parse B Mar 11, 2026 · 4 min read

Hematology Acute Myeloid Leukemia

Streptavidin-drug conjugates screen HSCT conditioning candidates without full ADC synthesis. Faster, cheaper, less toxic.

Streptavidin-drug conjugates streamline optimization of antibody-based hematopoietic stem cell transplant conditioning.

Streptavidin-drug conjugates enable rapid screening of antibody-targeted conditioning regimens for HSCT, bypassing costly full ADC synthesis to identify candidates that avoid chemotherapy/irradiation toxicity.

Figure 3.: Streptavidin-drug conjugates streamline optimization of antibody-based hematopoi

Parse B Mar 11, 2026 · 5 min read

Pulmonology Cystic Fibrosis Nontuberculous Mycobacteria Infections

Rifabutin tested against ETI: viable alternative to contraindicated rifampin. Dual therapy for NTM in CF now possible.

Evaluation of the drug interaction between rifabutin and elexacaftor/tezacaftor/ivacaftor (ETI).

These findings suggest rifabutin may be a viable alternative to contraindicated rifampin for treating nontuberculous mycobacteria infections in cystic fibrosis patients on ETI therapy, potentially…

Parse B Mar 11, 2026 · 2 min read

Pulmonology Cystic Fibrosis

Shallow metagenomic sequencing catches CF pathogens culture misses. Mycobacterium and Burkholderia spp. detected.

Shallow metagenomic shotgun sequencing improves detection of pathogenic species in cystic fibrosis respiratory samples.

Shallow metagenomic shotgun sequencing detected CF respiratory pathogens at species level that culture-based methods missed, including fastidious Mycobacterium spp. and closely related Burkholderia species.

Fig. 2: Shallow metagenomic shotgun sequencing improves detection of pathogenic species

Parse B Mar 11, 2026 · 3 min read

Rheumatology Osteoarthritis

Mast cells drive joint inflammation differently across arthritis types. Subtype-specific mediators as therapy targets.

The multifaceted role of mast cells in joint inflammation and arthritis.

A review of mast cell roles in joint inflammation reveals distinct activation pathways across arthritis subtypes, identifying specific mediators and phenotypes as potential therapeutic targets.

parsemedica Mar 10, 2026 · 2 min read

Hematology Autoimmune Lymphoproliferative Syndrome (ALPS)

LNP Fas gene therapy restores apoptosis in ALPS mice. A functional cure path beyond stem cell transplant.

Lipid Nanoparticle Fas Gene Therapy Suppresses Autoimmune Lymphoproliferative Syndrome in Mice.

This represents a novel gene therapy approach for ALPS, a genetic disease with no effective treatment options beyond stem cell transplantation, potentially offering a functional…

Figure 2.: Lipid Nanoparticle Fas Gene Therapy Suppresses Autoimmune Lymphoproliferative Sy

Parse B Mar 5, 2026 · 3 min read